Release date: 2017-03-17
According to Japanese media reports, the research team of the Japanese Institute of Physical Chemistry and the Center for Advanced Medical Center announced on March 16 in the American Journal of Medicine about the induction of pluripotent stem cells from female patients in the 70s who had "exudative age-related macular degeneration". (iPS cells) The retinal cells produced were transplanted into the clinical study of the female eye, and the operation was performed well after about two years of surgery. No abnormalities such as cancer were observed, and safety was confirmed.
This is the first operation of transplanting cells made of iPS cells. The project leader is the Takahashi political generation of Riken. Li Benben, director of the hospital's ophthalmology headquarters, said: "The postoperative progress is smooth and feels at ease."
On the other hand, the team pointed out that if the patient's own iPS cells are used, the cost will be increased by the time of transplantation. In the future, retinal cells made from other iPS cells, which can significantly reduce time and cost, will be transplanted as clinical studies.
According to the team, even if the woman does not use medical treatment, her eyesight will stop falling and be maintained. She will see signboards and convenience in doing housework, and her life will improve.
Clinical studies are designed to confirm whether there are safety issues such as cancer. The researchers introduced genes into iPS cells from cells collected from the skin of the female patient, then cultured them into retinal pigment epithelial cells and made a transplant film, which was transplanted into the female right eye in September 2014.
"Exudative age-related macular degeneration" is the proliferation of excess blood vessels inside the patient's retina, which can damage the retina, causing blurred vision and darkness, and even blindness.
The research team had previously prepared a second transplant, but found multiple genetic variants in the patient's iPS cells. Although it is judged that "transplantation will not cause safety problems", it is decided to not perform surgery for the sake of caution.
Source: World Wide Web
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