Medical Network February 26, Chinese researchers from the acupuncture treatment of asthma inspiration, the first discovery and verification of a bronchial asthma treatment target, providing ideas for the development of new drugs, related results recently published as a cover article published in the international academic journal "Science· Translational Medicine.
Asthma is a serious threat to human health common chronic respiratory disease, pathological mechanism is inconclusive. Acupuncture treatment of asthma is a summary of the experience of traditional Chinese medicine , and its principle has always been the subject of research by scientists.
According to one of the authors, Professor Deng Linhong from Changzhou University, the study found that after acupuncture at Dazhui, Fengmen, Feishu and other acupoints , not only the respiratory function of asthma patients was significantly improved, but also the metallothionein-2, which plays a key role in relieving asthma. The MT-2) content has also increased. Further studies have shown that the receptor for MT-2 on airway smooth muscle cells is actin-binding protein-2 (Transgelin-2).
“Transgelin-2 is the first new target for the treatment of bronchial asthma discovered and validated by Chinese researchers based on acupuncture therapy.†Deng Linhong said that the researchers screened nearly 6,000 compounds and found that the lead compound TSG12 can also effectively relax airway smooth muscle cells. It reduces the airway resistance and acts like acupuncture, which is expected to become a new drug for the treatment of asthma.
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