Release date: 2014-10-13
Using an aging biomarker called the Epigenetic Clock, researchers from the University of California Los Angeles found for the first time that obesity can accelerate the aging of the body's liver. In the journal PNAS, the study may help explain the pathogenesis of age-related diseases, such as liver cancer.
Although scientists have long speculated that obesity makes humans age faster, there is currently no valid evidence to prove it; in this paper, researchers have found that overweight can negatively and selectively affect the organization of human organisms; the researcher Professor Horvath said In this study, we evaluated the effects of obesity on the biological age of various tissues in the body, and the aging clock can use an organism's time-keeping mechanism to accurately calculate the ages of human organs, tissues, and various cell types. Focus on a biochemical process called methylation, methylation is the process of chemical modification of DNA molecules.
In this study, the researchers analyzed more than 1,200 human tissue samples, including 140 liver tissue samples, to study the association between epigenetic clock acceleration and body weight; when obesity does not affect the appearance of fat, muscle, or blood At the age of genetics, the researchers found that for every 10 increase in body mass index (BMI), the epigenetic age of the liver increased by 3.3 years. For example, a 5.5-foot, 140-pound female has a BMI of 23.3, while another woman with a weight of 200 pounds has a BMI of 33.3, and the latter's female liver will age more than the former. year.
The researchers said that for some people, the accelerated acceleration of aging due to obesity is very obvious, and some can even reach 10 years. And the rapid reduction in body weight caused by treatment does not reverse the process of aging, at least not in the short term. Researchers will continue to conduct in-depth research to determine whether premature aging of liver tissue in obese people can reduce the risk of diabetes and liver cancer in individuals. Researchers plan to develop new models to study the molecular mechanisms behind them.
The increase in epigenetic senescence in obese individuals' liver tissue is also crucial for the development of liver-related concomitant diseases common in obese individuals, such as insulin resistance and liver cancer. This study also supports the previous hypothesis that obesity can trigger Acceleration of the body's aging effect.
Source: Bio Valley
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