Pharmacological effects
1 antihypertensive effect, Aristolochia lucidum (Aristolochia root) crude preparation of a variety of animals, regardless of intravenous or oral administration can cause a certain degree of antihypertensive effect, the general decoction effect is stronger. Intravenous injections to anesthetized animals often cause dips, while intramuscular injections are slower and oral administration is slower. The antihypertensive effect of normal non-anaesthetized dogs is mild. After the formation of defensive conditioned reflex rats, their high-level nerve activity is disturbed and the intramuscular injection of pituitrin (2 units/kg) is performed intramuscularly, after the blood pressure has risen (about 30-40 mm Hg). Aqueous green tea, but also antihypertensive effect. The principle of antihypertensive action of crude preparations or refined extracts has been analyzed. It is believed that the antihypertensive effect does not directly inhibit the heart or dilate blood vessels (it has a contractile effect on isolated rabbit ear veins), but has nothing to do with the vagus nerve, but it does not work with the sympathetic nerves. The integrity of the system is relevant. There is no direct effect on the vasomotor center. After this extraction, the magnoloxicine was used as the active ingredient. The intravenous injection of 2 mg/kg to the anesthetized cats resulted in the immediate reduction of blood pressure. The blood pressure was reduced by 50 to 60% for 90 to 120 minutes. Blood pressure dogs, 6 mg / kg intravenous injection also has a significant antihypertensive effect, especially for the role of diastolic blood pressure. Magnoliaine does not have alkaloid-like effects, but has a nicotinic effect, especially the ganglion has a significant blocking effect, according to cat nictitating membrane test, its intensity is about 1/3-1/2 of C0. In isolated rat diaphragmatic tendon nerve specimens, it has an arrow poisonous effect, and its potency is about 1/100 to 1/200 of the arrow poison. Since it is a quaternary ammonium alkaloid, its absorption in the intestine is incomplete, and oral administration needs to be about 10 times larger than the injection volume. Although the magnoflorine or green woody preparation has no effect on the action of epinephrine, it has been reported that the decoction can fight the elevating effect of ephedrine. According to reports, acupoint injections can also cause rats to have blood pressure and acupoints with different effects.
2 The role of the gastrointestinal tract, folk use Aoki fragrant governance abdominal pain, clinical use of its crude formulations, but also cause nausea, vomiting and dizziness and other side effects. The emetic effect of Aristolochia vinegar is mainly caused by the ether-soluble acidic components contained therein, and the essential oil can also cause vomiting, but the effect is weak. The two components are not depressurized, so after the purification can eliminate this side effect.
3 Other effects, crude Aokimus sedative effect on mice. Refined extracts had no effect on the chemoreceptors in the spleen and lower extremities of rabbit uterus and cats. At high doses, there is some anti-diarrhea and in vitro inhibition of Shigella.
Concocted
Remove the impurities, separate the size bar, soak in water, remove, moisten evenly inside and outside, slice, and dry.
China Extract Powder For Use As Dietary Supplement Extract Powder, Extract Powder Manufacturer
Shaanxi Kang New Pharmaceutical co., Ltd. , https://www.kangnewpharma.com