Shanghai scientists reveal that hematopoietic stem cells regulate hormones or interfere with leukemia
July 26, 2018 Source: China News Author: Zheng Yingying high Xuelian
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences released on the 25th that the research team of the Institute and the Zheng Junke research group of Shanghai Jiaotong University jointly revealed that luteinizing hormone is the first to maintain the stability of hematopoietic stem cells. Important regulatory functions, the current papers have been published in the internationally renowned academic journal The EMBO Journal (European Journal of Molecular Biology).
Luteinizing hormone is a pituitary hormone secreted by human puberty. Its "work" is involved in regulating the maturity of the reproductive system, but in this study, researchers have discovered another function of luteinizing hormone - Regulate the number of hematopoietic stem cells in adolescent mice. Once hematopoietic stem cells lose their "induction" to luteinizing hormone, they will continue to expand during puberty, eventually leading to excessive hematopoiesis and leukocytosis in the bone marrow, which is followed by an acceleration of the leukemia process.
Subsequent animal experiments have shown that if the hematopoietic stem cells of mice cannot be "sensitized" to adolescent luteinizing hormone by genetic modification, hematopoietic stem cells in the bone marrow of mice will be over-amplified, and peripheral blood leukocytes will increase abnormally, which proves that resistance Breaking the signal of luteinizing hormone will accelerate the onset of leukemia.
The hematopoietic stem cells in the bone marrow are the "primary ancestors" responsible for generating all the blood cells of the human body. They are rapidly expanded after birth, and grow to "brake" after puberty, and the number gradually stabilizes. The researchers pointed out that this work reveals a hidden "biological clock" in the body. Once the hematopoietic stem cells enter puberty, they will be "emergency braking". If the "brake pads" are broken, it will cause blood diseases and even leukemia; How to use luteinizing hormone to intervene or prevent leukemia progression remains to be further studied.
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